Melanie Lietzenmayer

Academic Education

June 2018 – Present
Doctoral Studies within the international PhD program Immunity in Cancer and Allergy, Laboratory of Dr. Iris Gratz, Department of Biosciences, Paris-Lodron-Universität Salzburg

Oct. 2014 – May 2018
Master’s program Biology, area of studies: Molecular Biology/Immunology, Paris-Lodron-Universität Salzburg
Master Thesis: The Role of Long Noncoding RNAs in CD8+ T Cell-mediated Responses to Bacterial Infection

Oct. 2010 – Nov. 2013
Bachelor’s program Biology, area of studies: Molecular Biology/Genetics, Paris-Lodron-Universität Salzburg
Bachelor Thesis: Reprogramming: An Overview over Induced Pluripotent Stem Cells

Professional Career

March 2016 – Dec. 2016
Master Thesis, Laboratory of Richard Flavell, PhD., FRS, Immunobiology Department, Yale School of Medicine, Yale University
Work on long noncoding RNAs differentially expressed in CD8+ T cells in the context of Listeria monocytogenes infection. Involved in developing a new humanized mouse model and testing antibody immunotherapy in tumor bearing humanized mice

Oct. 2015 – Jan. 2016
Lab Assistant, Laboratory of Prof. Josef Thalhamer, Division of Allergy and Immunology, Department of Molecular Biology, Paris-Lodron-Universität Salzburg

Oct. 2013 – Jan. 2014
Internship, Laboratory for Immunological and Molecular Cancer Research (LIMCR), Salzburg Cancer Research Institute, Salzburg, Austria
I performed RNA preparation, Flow Cytometry, Western Blots, ELISAs, qRT-PCR, RNA microarrays, and worked in cell culture

Grants

2016
Scholarship for short-term scientific work abroad

Publications

Herndler-Brandstetter, D., Ishigame, H., Shinnakasu, R., Plajer, V., Stecher, C., Zhao, J., Lietzenmayer, M., Kroehling, L., Takumi, A., Kometani, K., Inoue, T., Kluger, Y., Kaech, S.M., Kurosaki, T., Okada, T., Flavell, R.A. KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity. 48(4), 716-729 (2018).

Ring, N.G., Herndler-Brandstetter, D., Weiskopf, K., Shan, L., Volkmer, J.P., George, B.M., Lietzenmayer, M., McKenna, K.M., Naik, T.J., McCarty, A., Zheng, Y., Ring, A.M., Flavell, R.A., Weissman, I.L. Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proc Natl Acad Sci U S A. 114(49), E10578-E10585 (2017).

Herndler-Brandstetter, D., Shan, L., Yao, Y., Stecher, C., Plajer, V., Lietzenmayer, M., Strowig, T., de Zoete, M.R., Palm, N.W., Chen, J., Blish, C.A., Frleta, D., Gurer, C., Macdonald, L.E., Murphy, A.J., Yancopoulos, G.D., Montgomery, R.R., Flavell, R.A. Humanized mouse model supports development, function, and tissue residency of human natural killer cells. Proc Natl Acad Sci U S A. 114(45), E9626-E9634 (2017).

Kurtaj, A., Hillebrand, C., Fichtinger, G., Hattinger, E., Lietzenmayer, M., Machado, Y., Scheiblhofer, S., Stoecklinger, A., Thalhamer, T., Suessner, S., Danzer, M., Keplinger, S., Weinberger, J., Schaller, S., Winkler, S., Gabriel, C., Thalhamer, J., Weiss, R. Natural protective immunity against grass pollen allergy is maintained by a diverse spectrum of response types. J Allergy Clin Immunol. 140(6), 1746-1749 (2017).

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