Publications

Aglas L, Soh WT, Kraiem A, Wenger M, Brandstetter H, Ferreira F

Ligand Binding of PR-10 Proteins with a Particular Focus on the Bet v 1 Allergen Family

Curr Allergy Asthma Rep 20(7), (2020)

DOI: 10.1007/s11882-020-00918-4

Althammer M, Blöchl C, Reischl R, Huber CG, Tenhaken R

Phosphoglucomutase Is Not the Target for Galactose Toxicity in Plants

Front Plant Sci 11, (2020)

DOI: 10.3389/fpls.2020.00167

Bauer R, Rauch I

The NAIP/NLRC4 inflammasome in infection and pathology

Mol Aspects Med , 100863 (2020)

DOI: 10.1016/j.mam.2020.100863

Blöchl C, Regl C, Huber CG, Winter P, Weiss R, Wohlschlager T

Towards middle-up analysis of polyclonal antibodies: subclass-specific N-glycosylation profiling of murine immunoglobulin G (IgG) by means of HPLC-MS

bioRxiv , (2020)

DOI: 10.1101/2020.07.16.205930

Boraschi D, Alijagic A, Auguste M, Barbero F, Ferrari E, Hernadi S, Mayall C, Michelini S, Pacheco NIN, Prinelli A, Swart E, Swartzwelter BJ, Bast{\'{u}}s NG, Canesi L, Drobne D, Duschl A, Ewart M, Horejs-Hoeck J, Italiani P, Kemmerling B, Kille P, Prochazkova P, Puntes VF, Spurgeon DJ, Svendsen C, Wilde CJ, Pinsino A

Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species

Small 16(21), 2000598 (2020)

DOI: 10.1002/smll.202000598

Elmer DP, Strobl V, Stockmaier G, Dang H, Wiederstein M, Licha D, Strobl A, Sternberg C, Tesanovic S, Grund-Groeschke S, Gruber W, Wolff F, Moriggl R, Risch A, Reischl R, Huber CG, Horejs-Hoeck J, Aberger F

Oncogenic GLI1 and STAT1/3 activation drives immunosuppressive tryptophan/kynurenine metabolism via synergistic induction of IDO1 in skin cancer cells

bioRxiv , (2020)

DOI: 10.1101/2020.05.04.074757

Gutjahr JC, Bayer E, Yu X, Laufer JM, Höpner JP, Tesanovic S, Härzschel A, Auer G, Rieß T, Salmhofer A, Szenes E, Haslauer T, Durand-Onayli V, Ramspacher A, Pennisi SP, Artinger M, Zaborsky N, Chigaev A, Aberger F, Neureiter D, Pleyer L, Legler DF, Orian-Rousseau V, Greil R, Hartmann TN

CD}44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity

Haematologica , haematol.2019.231944 (2020)

DOI: 10.3324/haematol.2019.231944

Höllbacher B, Duhen T, Motley S, Klicznik MM, Gratz IK, Campbell DJ

Transcriptomic profiling of human effector and regulatory T cell subsets identifies predictive population signatures

bioRxiv , (2020)

DOI: 10.1101/2020.05.13.093567

Johnson L, Duschl A, Himly M

Nanotechnology-Based Vaccines for Allergen-Specific Immunotherapy: Potentials and Challenges of Conventional and Novel Adjuvants under Research

Vaccines 8(2), 237 (2020)

DOI: 10.3390/vaccines8020237

Joubert AI, Geppert M, Johnson L, Mills-Goodlet R, Michelini S, Korotchenko E, Duschl A, Weiss R, Horejs-Höck J, Himly M

Mechanisms of Particles in Sensitization, Effector Function and Therapy of Allergic Disease

Front Immunol 11, (2020)

DOI: 10.3389/fimmu.2020.01334

Joubert IA, Kovacs D, Scheiblhofer S, Winter P, Korotchenko E, Strandt H, Weiss R

Mast cells and γδT cells are largely dispensable for adaptive immune responses after laser-mediated epicutaneous immunization

Vaccine 38(5), 1015–1024 (2020)

DOI: 10.1016/j.vaccine.2019.11.051

Kamath SD, Scheiblhofer S, Johnson CM, Machado Y, McLean T, Taki AC, Ramsland PA, Iyer S, Joubert I, Hofer H, Wallner M, Thalhamer J, Rolland J, O’Hehir R, Briza P, Ferreira F, Weiss R, Lopata AL

Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin

Allergy , (2020)

DOI: 10.1111/all.14410

Klicznik MM, Benedetti A, Gail LM, Varkhande SR, Holly R, Laimer M, Stoecklinger A, Sir A, Reitsamer R, Neuper T, Horejs-Hoeck J, Rosenblum MD, Campbell DJ, Murauer EM, Gratz IK

A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin

Sci Rep 10(1), (2020)

DOI: 10.1038/s41598-020-67430-7

Korotchenko E, Moya R, Scheiblhofer S, Joubert IA, Horejs-Hoeck J, Hauser M, Calzada D, Iraola V, Carn{\'{e}}s J, Weiss R

Laser-facilitated epicutaneous immunotherapy with depigmented house dust mite extract alleviates allergic responses in a mouse model of allergic lung inflammation

Allergy 75(5), 1217–1228 (2020)

DOI: 10.1111/all.14164

Mills-Goodlet R, Schenck M, Chary A, Geppert M, Serchi T, Hofer S, Hofstätter N, Feinle A, Hüsing N, Gutleb AC, Himly M, Duschl A

Biological effects of allergen–nanoparticle conjugates: uptake and immune effects determined on hAELVi cells under submerged vs. air–liquid interface conditions

Environ Sci Nano 7(7), 2073–2086 (2020)

DOI: 10.1039/c9en01353a

Oberhuber M, Pecoraro M, Rusz M, Oberhuber G, Wieselberg M, Haslinger P, Gurnhofer E, Schlederer M, Limberger T, Lagger S, Pencik J, Kodajova P, Högler S, Stockmaier G, Grund-Gröschke S, Aberger F, Bolis M, Theurillat J, Wiebringhaus R, Weiss T, Haitel A, Brehme M, Wadsak W, Griss J, Mohr T, Hofer A, Jäger A, Pollheimer J, Egger G, Koellensperger G, Mann M, Hantusch B, Kenner L

STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer

Mol Syst Biol 16(4), (2020)

DOI: 10.15252/msb.20199247

Pinheiro DF, Szenes-Nagy AB, Maurano MM, Lietzenmayer M, Klicznik MM, Holly R, Kirchmeier D, Kitzmueller S, Achatz-Straussberger G, Rosenblum MD, Thalhamer J, Abbas AK, Gratz IK

Cutting Edge: Tissue Antigen Expression Levels Fine-Tune T Cell Differentiation Decisions In Vivo

J Immunol , (2020)

DOI: 10.4049/jimmunol.1901094

Reinders J, Altenbuchinger M, Limm K, Schwarzfischer P, Scheidt T, Strasser L, Richter J, Szczepanowski M, Huber CG, Klapper W, Spang R, Oefner PJ

Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue

Sci Rep 10(1), (2020)

DOI: 10.1038/s41598-020-64212-z

Samonig L, Loipetzberger A, Blöchl C, Rurik M, Kohlbacher O, Aberger F, Huber CG

Proteins and Molecular Pathways Relevant for the Malignant Properties of Tumor-Initiating Pancreatic Cancer Cells

Cells 9(6), 1397 (2020)

DOI: 10.3390/cells9061397

Schamschula E, Hagmann W, Assenov Y, Hedtfeld S, Farag AK, Roesner LM, Wiehlmann L, Stanke F, Fischer S, Risch A, Tümmler B

Immunotyping of clinically divergent p.Phe508del homozygous monozygous cystic fibrosis twins

J Cyst Fibros , (2020)

DOI: 10.1016/j.jcf.2020.06.009

Scheidt T, Alka O, Gonczarowska-Jorge H, Gruber W, Rathje F, Dell’Aica M, Rurik M, Kohlbacher O, Zahedi RP, Aberger F, Huber CG

Phosphoproteomics of short-term hedgehog signaling in human medulloblastoma cells

Cell Commun Signal 18(1), (2020)

DOI: 10.1186/s12964-020-00591-0

Silva ES, Huber S, Alcantara-Neves NM, Asam C, Silveira EF, Belitardo EMMA, Aglas L, Wallner M, Gadermaier G, Briza P, Karner I, Torres RT, Alvarez JRU, Wuenschmann S, Chapman M, Ferreira F, Pinheiro CS

N-terminal peptide deletion influences immunological and structural features of Blo t 5

Allergy 75(6), 1503–1507 (2020)

DOI: 10.1111/all.14176

Soh WT, Demir F, Dall E, Perrar A, Dahms SO, Kuppusamy M, Brandstetter H, Huesgen PF

ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease

Anal Chem 92(4), 2961–2971 (2020)

DOI: 10.1021/acs.analchem.9b03604

Strandt H, Voluzan O, Niedermair T, Ritter U, Thalhamer J, Malissen B, Stoecklinger A, Henri S

Macrophages and Fibroblasts Differentially Contribute to Tattoo Stability

Dermatology , 1–7 (2020)

DOI: 10.1159/000506540

Szenes E, Härzschel A, Decker S, Tissino E, Pischeli J, Gutjahr JC, Kissel S, Pennisi S, Höpner JP, Egle A, Zaborsky N, Dierks C, Follo M, Chigaev A, Zucchetto A, Greil R, Gattei V, Hartmann TN

TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia

Leukemia 34(9), 2498–2502 (2020)

DOI: 10.1038/s41375-020-0759-3

Winter P, Stubenvoll S, Scheiblhofer S, Joubert IA, Strasser L, Briganser C, Tuck SW, Hofer F, Kamenik AS, Dietrich V, Michelini S, Laimer J, Lackner P, Horejs-Hoeck J, Tollinger M, Liedl KR, Brandstetter J, Huber CG, Richard W

In silico design of Phl p 6 variants with altered folding stability significantly impacts antigen processing, immunogenicity and immune polarization

bioRxiv , (2020)

DOI: 10.1101/2020.02.26.967265

C, Diechler , Posselt , Wessler

Tyrosine Kinases in Helicobacter pylori Infections and Gastric Cancer

Toxins 11(10), 591 (2019)

DOI: 10.3390/toxins11100591

Eichhorn S, Hörschläger A, Steiner M, Laimer J, Jensen BM, Versteeg SA, Pablos I, Briza P, Jongejan L, Rigby N, Asturias JA, Portol{\'{e}}s A, Fernandez-Rivas M, Papadopoulos NG, Mari A, Poulsen LK, Lackner P, Ree R, Ferreira F, Gadermaier G

Rational Design, Structure–Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants

Mol Nutr Food Res 63(18), 1900336 (2019)

DOI: 10.1002/mnfr.201900336

Grund-Gröschke S, Ortner D, Szenes-Nagy AB, Zaborsky N, Weiss R, Neureiter D, Wipplinger M, Risch A, Hammerl P, Greil R, Sibilia M, Gratz IK, Stoitzner P, Aberger F

Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity

bioRxiv , (2019)

DOI: 10.1101/768796

Klicznik MM, Morawski PA, Höllbacher B, Varkhande SR, Motley SJ, Kuri-Cervantes L, Goodwin E, Rosenblum MD, Long SA, Brachtl G, Duhen T, Betts MR, Campbell DJ, Gratz IK

Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals

Sci Immunol 4(37), eaav8995 (2019)

DOI: 10.1126/sciimmunol.aav8995

Pablos I, Egger M, Vejvar E, Reichl V, Briza P, Zennaro D, Rafaiani C, Pickl W, Bohle B, Mari A, Ferreira F, Gadermaier G

Similar Allergenicity to Different Artemisia Species Is a Consequence of Highly Cross-Reactive Art v 1-Like Molecules

Medicina (Mex) 55(8), 504 (2019)

DOI: 10.3390/medicina55080504

Parigger T, Greil R, Zaborsky N

Mouse models to decipher anti-tumor immunity

Oncotarget 10(49), 5005–5006 (2019)

DOI: 10.18632/oncotarget.27111

Pereira GA, da Silva EB, Braga SF, Leite PG, Martins LC, Vieira RP, Soh WT, Villela FS, Costa FM, Ray D, de Andrade SF, Brandstetter H, Oliveira RB, Caffrey CR, Machado FS, Ferreira RS

Discovery and characterization of trypanocidal cysteine protease inhibitors from the ‘malaria box’

Eur J Med Chem 179, 765–778 (2019)

DOI: 10.1016/j.ejmech.2019.06.062

Posselt G, Wiesauer M, Chichirau BE, Engler D, Krisch LM, Gadermaier G, Briza P, Schneider S, Boccellato F, Meyer TF, Hauser-Kronberger C, Neureiter D, Müller A, Wessler S

Helicobacter pylori-controlled c-Abl localization promotes cell migration and limits apoptosis

Cell Commun Signal 17(1), (2019)

DOI: 10.1186/s12964-019-0323-9

Samadi N, Klems M, Heiden D, Bauer R, Kitzmüller C, Weidmann E, Ret D, Ondracek AS, Duschl A, Horejs-Hoeck J, Untersmayr E

Nitrated food proteins induce a regulatory immune response associated with allergy prevention after oral exposure in a Balb/c mouse food allergy model

Allergy 75(2), 412–422 (2019)

DOI: 10.1111/all.14030

Sarajlic M, Neuper T, Quiroz KTF, Michelini S, Vetter J, Schaller S, Horejs-Hoeck J

IL-1β Induces SOCS2 Expression in Human Dendritic Cells

Int J Mol Sci 20(23), 5931 (2019)

DOI: 10.3390/ijms20235931

Schubert M, Zaborsky N, Schubert M, Gassner FJ, Geisberger R

NGS-based analysis of the mouse B-cell receptor repertoire

Protocol Exchange , (2019)

DOI: 10.1038/protex.2018.110

Soh WT, Aglas L, Mueller GA, Gilles S, Weiss R, Scheiblhofer S, Huber S, Scheidt T, Thompson PM, Briza P, London RE, Traidl-Hoffmann C, Cabrele C, Brandstetter H, Ferreira F

Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity

Allergy 74(12), 2382–2393 (2019)

DOI: 10.1111/all.13948

Wildner S, Griessner I, Stemeseder T, Regl C, Soh WT, Stock LG, Völker T, Alessandri C, Mari A, Huber CG, Stutz H, Brandstetter H, Gadermaier G

Boiling down the cysteine-stabilized LTP fold – loss of structural and immunological integrity of allergenic Art v 3 and Pru p 3 as a consequence of irreversible lanthionine formation

Mol Immunol 116, 140–150 (2019)

DOI: 10.1016/j.molimm.2019.10.012

Aglas L, Gilles S, Bauer R, Huber S, Araujo GR, Mueller G, Scheiblhofer S, Amisi M, Dang H, Briza P, Bohle B, Horejs-Hoeck J, Traidl-Hoffmann C, Ferreira F

Context matters: TH2 polarization resulting from pollen composition and not from protein-intrinsic allergenicity

J Allergy Clin Immunol 142(3), 984–987.e6 (2018)

DOI: 10.1016/j.jaci.2018.05.004

Asam C, Roulias A, Parigiani M, Haab A, Wallner M, Wolf M, Briza P, Bohle B, Ferreira F, Hauser M

Harmonization of the Genetic Code Effectively Enhances the Recombinant Production of the Major Birch Pollen Allergen Bet v 1

Int Arch Allergy Immunol 177(2), 116–122 (2018)

DOI: 10.1159/000489707

Binder S, Luciano M, Horejs-Hoeck J

The cytokine network in acute myeloid leukemia (AML): A focus on pro- and anti-inflammatory mediators

Cytokine Growth Factor Rev 43, 8–15 (2018)

DOI: 10.1016/j.cytogfr.2018.08.004

Dall E, Hollerweger JC, Dahms SO, Cui H, Häussermann K, Brandstetter H

Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states

J Biol Chem 293(34), 13151–13165 (2018)

DOI: 10.1074/jbc.ra118.002154

Durand-Onayli V, Haslauer T, Härzschel A, Hartmann T

Rac GTPases in Hematological Malignancies

Int J Mol Sci 19(12), 4041 (2018)

DOI: 10.3390/ijms19124041

Grotz B, Geppert M, Mills-Goodlet R, Hofer S, Hofstätter N, Asam C, Feinle A, Kocsis K, Berger T, Diwald O, Hüsing N, Wallner M, Ferreira F, Duschl A, Himly M

Biologic effects of nanoparticle-allergen conjugates: time-resolved uptake using an in vitro lung epithelial co-culture model of A549 and THP-1 cells

Environ Sci Nano 5(9), 2184–2197 (2018)

DOI: 10.1039/c8en00243f

Guo S, Briza P, Magdolen V, Brandstetter H, Goettig P

Activation and activity of glycosylated KLKs 3, 4 and 11

Biol Chem 399(9), 1009–1022 (2018)

DOI: 10.1515/hsz-2018-0148

Gusenkov S, Stutz H

Top-down and bottom-up characterization of nitrated birch pollen allergen Bet v 1a with CZE hyphenated to an Orbitrap mass spectrometer

Electrophoresis 39(9-10), 1190–1200 (2018)

DOI: 10.1002/elps.201700413

Gutjahr JC, Szenes E, Tschech L, Asslaber D, Schlederer M, Roos S, Yu X, Girbl T, Sternberg C, Egle A, Aberger F, Alon R, Kenner L, Greil R, Orian-Rousseau V, Hartmann TN

Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

Blood 131(12), 1337–1349 (2018)

DOI: 10.1182/blood-2017-08-802462

Hollerweger JC, Hoppe IJ, Regl C, Stock LG, Huber CG, Lohrig U, Stutz H, Brandstetter H

Analytical Cascades of Enzymes for Sensitive Detection of Structural Variations in Protein Samples

Anal Chem 90(8), 5055–5065 (2018)

DOI: 10.1021/acs.analchem.7b04874

Klicznik MM, Benedetti A, Stoecklinger A, Campbell DJ, Gratz IK

Circulating CD4+ memory T cells give rise to a CD69+ resident memory T cell population in non-inflamed human skin

bioRxiv , (2018)

DOI: 10.1101/490094

Klicznik MM, Szenes-Nagy AB, Campbell DJ, Gratz IK

Taking the lead – how keratinocytes orchestrate skin T cell immunity

Immunol Lett 200, 43–51 (2018)

DOI: 10.1016/j.imlet.2018.06.009

Michelini S, Sarajlic M, Duschl A, Horejs-Hoeck J

IL-1β induces expression of costimulatory molecules and cytokines but not immune feedback regulators in dendritic cells

Hum Immunol 79(8), 610–615 (2018)

DOI: 10.1016/j.humimm.2018.06.002

Moraes AH, Asam C, Almeida FCL, Wallner M, Ferreira F, Valente AP

Structural basis for cross-reactivity and conformation fluctuation of the major beech pollen allergen Fag s 1

Sci Rep 8(1), (2018)

DOI: 10.1038/s41598-018-28358-1

Prutsch N, Gurnhofer E, Suske T, Liang HC, Schlederer M, Roos S, Wu LC, Simonitsch-Klupp I, Alvarez-Hernandez A, Kornauth C, Leone DA, Svinka J, Eferl R, Limberger T, Aufinger A, Shirsath N, Wolf P, Hielscher T, Sternberg C, Aberger F, Schmoellerl J, Stoiber D, Strobl B, Jäger U, Staber PB, Grebien F, Moriggl R, Müller M, Inghirami GG, Sanda T, Look AT, Turner SD, Kenner L, Merkel O

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

Leukemia 33(3), 696–709 (2018)

DOI: 10.1038/s41375-018-0239-1

Schinagl A, Kerschbaumer RJ, Sabarth N, Douillard P, Scholz P, Voelkel D, Hollerweger JC, Goettig P, Brandstetter H, Scheiflinger F, Thiele M

Role of the Cysteine 81 Residue of Macrophage Migration Inhibitory Factor as a Molecular Redox Switch

Biochemistry (Mosc) 57(9), 1523–1532 (2018)

DOI: 10.1021/acs.biochem.7b01156

Schubert M, Greil R, Geisberger R

Risks and chances of aberrant DNA repair in cancer

Oncoscience 5(9-10), 256–257 (2018)

DOI: 10.18632/oncoscience.459

Schubert M, Hackl H, Gassner FJ, Greil R, Geisberger R

Investigating epigenetic effects of activation-induced deaminase in chronic lymphocytic leukemia

PLoS One 13(12), e0208753 (2018)

DOI: 10.1371/journal.pone.0208753

Sternberg C, Gruber W, Eberl M, Tesanovic S, Stadler M, Elmer DP, Schlederer M, Grund S, Roos S, Wolff F, Kaur S, Mangelberger D, Lehrach H, Hache H, Wierling C, Laimer J, Lackner P, Wiederstein M, Kasper M, Risch A, Petzelbauer P, Moriggl R, Kenner L, Aberger F

Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma

Int J Cancer 143(11), 2943–2954 (2018)

DOI: 10.1002/ijc.31724

Swoboda A, Soukup R, Kinslechner K, Wingelhofer B, Schörghofer D, Sternberg C, Pham HTT, Vallianou M, Horvath J, Stoiber D, Kenner L, Larue L, Poli V, Beermann F, Yokota T, Kubicek S, Krausgruber T, Rendeiro AF, Bock C, Zenz R, Kovacic B, Aberger F, Hengstschläger M, Petzelbauer P, Mikula M, Moriggl R

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathway

bioRxiv , (2018)

DOI: 10.1101/422832

Tripolt S, Knab VM, Neubauer HA, Elmer DP, Aberger F, Moriggl R, Fux DA

Opioids trigger breast cancer metastasis through E-Cadherin downregulation and STAT3 activation promoting epithelial-mesenchymal transition

bioRxiv , (2018)

DOI: 10.1101/443663

Wolf M, Aglas L, Twaroch TE, Steiner M, Huber S, Hauser M, Hofer H, Parigiani MA, Ebner C, Bohle B, Briza P, Neubauer A, Stolz F, Wallner M, Ferreira F

Endolysosomal protease susceptibility of Amb a 1 as a determinant of allergenicity

J Allergy Clin Immunol 141(4), 1488–1491.e5 (2018)

DOI: 10.1016/j.jaci.2017.10.027

Zaborsky N, Gassner FJ, Höpner JP, Schubert M, Hebenstreit D, Stark R, Asslaber D, Steiner M, Geisberger R, Greil R, Egle A

Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development

Leukemia 33(4), 957–968 (2018)

DOI: 10.1038/s41375-018-0260-4

Zauner FB, Dall E, Regl C, Grassi L, Huber CG, Cabrele C, Brandstetter H

Crystal Structure of Plant Legumain Reveals a Unique Two-Chain State with pH-Dependent Activity Regulation

Plant Cell 30(3), 686–699 (2018)

DOI: 10.1105/tpc.17.00963

Zauner FB, Elsässer B, Dall E, Cabrele C, Brandstetter H

Structural analyses of Arabidopsis thaliana legumain γ reveal differential recognition and processing of proteolysis and ligation substrates

J Biol Chem 293(23), 8934–8946 (2018)

DOI: 10.1074/jbc.m117.817031

Aberger F, Hutterer E, Sternberg C, del Burgo PJ, Hartmann TN

Acute myeloid leukemia – strategies and challenges for targeting oncogenic Hedgehog/GLI signaling

Cell Commun Signal 15(1), (2017)

DOI: 10.1186/s12964-017-0163-4

Braga SFP, Martins LC, da Silva EB, Sales PA, Murta SMF, Romanha AJ, Soh WT, Brandstetter H, Ferreira RS, de Oliveira RB

Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification

Bioorgan Med Chem 25(6), 1889–1900 (2017)

DOI: 10.1016/j.bmc.2017.02.009

Catakovic K, Gassner FJ, Ratswohl C, Zaborsky N, Rebhandl S, Schubert M, Steiner M, Gutjahr JC, Pleyer L, Egle A, Hartmann TN, Greil R, Geisberger R

TIGIT expressing CD4+ T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia

OncoImmunology 7(1), e1371399 (2017)

DOI: 10.1080/2162402x.2017.1371399

da Silva ES, Asam C, Lackner P, Hofer H, Wallner M, Pinheiro CS, Alc{\^{a}}ntara-Neves NM, Ferreira F

Allergens of Blomia tropicalis: An Overview of Recombinant Molecules

Int Arch Allergy Immunol 172(4), 203–214 (2017)

DOI: 10.1159/000464325

Elsässer B, Zauner FB, Messner J, Soh WT, Dall E, Brandstetter H

Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations

ACS} Catalysis 7(9), 5585–5593 (2017)

DOI: 10.1021/acscatal.7b01505

Gassner FJ, Schubert M, Rebhandl S, Spandl K, Zaborsky N, Catakovic K, Blaimer S, Hebenstreit D, Greil R, Geisberger R

Imprecision and DNA Break Repair Biased towards Incompatible End Joining in Leukemia

Mol Cancer Res 16(3), 428–438 (2017)

DOI: 10.1158/1541-7786.mcr-17-0373

Greil R, Hutterer E, Hartmann TN, Pleyer L

Reactivation of dormant anti-tumor immunity – a clinical perspective of therapeutic immune checkpoint modulation

Cell Commun Signal 15(1), (2017)

DOI: 10.1186/s12964-016-0155-9

Gruber W, Peer E, Elmer DP, Sternberg C, Tesanovic S, del Burgo P, Coni S, Canettieri G, Neureiter D, Bartz R, Kohlhof H, Vitt D, Aberger F

Targeting class I histone deacetylases by the novel small molecule inhibitor 4 SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance

Int J Cancer 142(5), 968–975 (2017)

DOI: 10.1002/ijc.31117

Gruber W, Scheidt T, Aberger F, Huber CG

Understanding cell signaling in cancer stem cells for targeted therapy – can phosphoproteomics help to reveal the secrets?

Cell Commun Signal 15(1), (2017)

DOI: 10.1186/s12964-017-0166-1

Himly M, Mills-Goodlet R, Geppert M, Duschl A

Nanomaterials in the Context of Type 2 Immune Responses – Fears and Potentials

Front Immunol 8, (2017)

DOI: 10.3389/fimmu.2017.00471

Hirschl S, Ralser C, Asam C, Gangitano A, Huber S, Ebner C, Bohle B, Wolf M, Briza P, Ferreira F, Griesbeck C, Wallner M

Expression and Characterization of Functional Recombinant Bet v 1.0101 in the Chloroplast of Chlamydomonas reinhardtii

Int Arch Allergy Immunol 173(1), 44–50 (2017)

DOI: 10.1159/000471852

Hofer H, Asam C, Hauser M, Nagl B, Laimer J, Himly M, Briza P, Ebner C, Lang R, Hawranek T, Bohle B, Lackner P, Ferreira F, Wallner M

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Anal Bioanal Chem 405(27), 8945–8949 (2013)

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Weinberger EE, Himly M, Myschik J, Hauser M, Altmann F, Isakovic A, Scheiblhofer S, Thalhamer J, Weiss R

Generation of hypoallergenic neoglycoconjugates for dendritic cell targeted vaccination: A novel tool for specific immunotherapy

J Controlled Release 165(2), 101–109 (2013)

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Weinberger EE, Isakovic A, Scheiblhofer S, Ramsauer C, Reiter K, Hauser-Kronberger C, Thalhamer J, Weiss R

The influence of antigen targeting to sub-cellular compartments on the anti-allergic potential of a DNA vaccine

Vaccine 31(51), 6113–6121 (2013)

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Weiss R, Scheiblhofer S, Machado Y, Thalhamer J

New approaches to transcutaneous immunotherapy

Curr Opin Allergy Clin Immunol 13(6), 669–676 (2013)

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Wenger J, Klinglmayr E, Fröhlich C, Eibl C, Gimeno A, Hessenberger M, Puehringer S, Daumke O, Goettig P

Functional Mapping of Human Dynamin-1-Like GTPase Domain Based on X-ray Structure Analyses

PLoS One 8(8), e71835 (2013)

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Wolff F, Loipetzberger A, Gruber W, Esterbauer H, Aberger F, Frischauf AM

Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation

Oncogene 32(50), 5574–5581 (2013)

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Zucchetto A, Caldana C, Benedetti D, Tissino E, Rossi FM, Hutterer E, Pozzo F, Bomben R, Bo MD, D’Arena G, Zaja F, Pozzato G, Di Raimondo F, Hartmann TN, Rossi D, Gaidano G, Del Poeta G, Gattei V

CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism

Blood 122(19), 3317–3321 (2013)

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Asslaber D, Grössinger EM, Girbl T, Hofbauer SW, Egle A, Weiss L, Greil R, Hartmann TN

Mimicking the microenvironment in chronic lymphocytic leukaemia – where does the journey go?

Br J Haematol 160(5), 711–714 (2012)

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Bach D, Weiss R, Hessenberger M, Kitzmueller S, Weinberger EE, Krautgartner WD, Hauser-Kronberger C, Boehler C, Thalhamer J, Scheiblhofer S

Transcutaneous immunotherapy via laser-generated micropores efficiently alleviates allergic asthma in Phl p 5-sensitized mice

Allergy 67(11), 1365–1374 (2012)

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Eberl M, Klingler S, Mangelberger D, Loipetzberger A, Damhofer H, Zoidl K, Schnidar H, Hache H, Bauer H, Solca F, Hauser-Kronberger C, Ermilov AN, Verhaegen ME, Bichakjian CK, Dlugosz AA, Nietfeld W, Sibilia M, Lehrach H, Wierling C, Aberger F

Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

EMBO Mol Med 4(3), 218–233 (2012)

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Eibl C, Grigoriu S, Hessenberger M, Wenger J, Puehringer S, Pinheiro AS, Wagner RN, Proell M, Reed JC, Page R, Diederichs K, Peti W

Structural and Functional Analysis of the NLRP4 Pyrin Domain

Biochemistry (Mosc) 51(37), 7330–7341 (2012)

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Girbl T, Hinterseer E, Grossinger EM, Asslaber D, Oberascher K, Weiss L, Hauser-Kronberger C, Neureiter D, Kerschbaum H, Naor D, Alon R, Greil R, Hartmann TN

CD40-Mediated Activation of Chronic Lymphocytic Leukemia Cells Promotes Their CD44-Dependent Adhesion to Hyaluronan and Restricts CCL21-Induced Motility

Cancer Res 73(2), 561–570 (2012)

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Horejs-Hoeck J, Schwarz H, Lamprecht S, Maier E, Hainzl S, Schmittner M, Posselt G, Stoecklinger A, Hawranek T, Duschl A

Dendritic Cells Activated by IFN-γ/STAT1 Express IL-31 Receptor and Release Proinflammatory Mediators upon IL-31 Treatment

J Immunol 188(11), 5319–5326 (2012)

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Purification, crystallization and X-ray diffraction analysis of human dynamin-related protein 1 GTPase-GED fusion protein

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Crystallographically Mapped Ligand Binding Differs in High and Low IgE Binding Isoforms of Birch Pollen Allergen Bet v 1

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Cooperative Hedgehog-EGFR signaling

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Pichler P, Mazanek M, Dusberger F, Weilnböck L, Huber CG, Stingl C, Luider TM, Straube WL, Köcher T, Mechtler K

SIMPATIQCO: A Server-Based Software Suite Which Facilitates Monitoring the Time Course of LC-MS Performance Metrics on Orbitrap Instruments

J Proteome Res 11(11), 5540–5547 (2012)

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Carnobacterium divergens – a dominating bacterium of pork meat juice

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Stoecklinger A, Scheiblhofer S, Roesler E, Lang A, Fastner G, Sedlmayer F, Lang R, Danzer M, Thalhamer J, Weiss R

T Cell Epitopes of the Timothy Grass Pollen Allergen Phl p 5 of Mice and Men and the Detection of Allergen-Specific T Cells Using Class II Ultimers

Int Arch Allergy Immunol 158(4), 326–334 (2012)

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Weiss R, Hessenberger M, Kitzmüller S, Bach D, Weinberger EE, Krautgartner WD, Hauser-Kronberger C, Malissen B, Boehler C, Kalia YN, Thalhamer J, Scheiblhofer S

Transcutaneous vaccination via laser microporation

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Weiss R, Scheiblhofer S, Roesler E, Weinberger E, Thalhamer J

mRNA vaccination as a safe approach for specific protection from type I allergy

Expert Rev Vaccines 11(1), 55–67 (2012)

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Ackaert C, Kofler S, Posselt G, Gusenkov S, Gadermaier G, Asam C, Stutz H, Brandstetter H, Duschl A, Horejs-Höck J, Oostingh GJ

Impact of nitration on the immunogenicity of Bet v 1.0101

Immunology 135, 52–212 (2011)

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Brachtl G, Sahakyan K, Denk U, Girbl T, Alinger B, Hofbauer SW, Neureiter D, Hofbauer JP, Egle A, Greil R, Hartmann TN

Differential Bone Marrow Homing Capacity of VLA-4 and CD38 High Expressing Chronic Lymphocytic Leukemia Cells

PLoS One 6(8), e23758 (2011)

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Eckhard U, Schönauer E, Nüss D, Brandstetter H

Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis

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Erler A, Hawranek T, Krückemeier L, Asam C, Egger M, Ferreira F, Briza P

Proteomic profiling of birch (Betula verrucosa) pollen extracts from different origins

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Hauser M, Asam C, Himly M, Palazzo P, Voltolini S, Montanari C, Briza P, Bernardi ML, Mari A, Ferreira F, Wallner M

Bet v 1-like pollen allergens of multiple Fagales species can sensitize atopic individuals

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The NLRP12 Pyrin Domain: Structure, Dynamics, and Functional Insights

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Posselt G, Schwarz H, Duschl A, Horejs-Hoeck J

Suppressor of Cytokine Signaling 2 Is a Feedback Inhibitor of TLR-Induced Activation in Human Monocyte-Derived Dendritic Cells

J Immunol 187(6), 2875–2884 (2011)

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Wallner M, Hauser M, Himly M, Zaborsky N, Mutschlechner S, Harrer A, Asam C, Pichler U, van Ree R, Briza P, Thalhamer J, Bohle B, Achatz G, Ferreira F

Reshaping the Bet v 1 fold modulates TH polarization

J Allergy Clin Immunol 127(6), 1571–1578.e9 (2011)

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Desch P, Asslaber D, Kern D, Schnidar H, Mangelberger D, Alinger B, Stoecher M, Hofbauer SW, Neureiter D, Tinhofer I, Aberger F, Hartmann TN, Greil R

Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells

Oncogene 29(35), 4885–4895 (2010)

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Hauser M, Roulias A, Ferreira F, Egger M

Panallergens and their impact on the allergic patient

Allergy Asthma Cl Im 6(1), 1 (2010)

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Maier E, Hebenstreit D, Posselt G, Hammerl P, Duschl A, Horejs-Hoeck J

Inhibition of Suppressive T Cell Factor 1 (TCF-1) Isoforms in Naive CD4+T Cells Is Mediated by IL-4/STAT6 Signaling

J Biol Chem 286(2), 919–928 (2010)

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Pinheiro AS, Proell M, Eibl C, Page R, Schwarzenbacher R, Peti W

Three-dimensional Structure of the NLRP7 Pyrin Domain

J Biol Chem 285(35), 27402–27410 (2010)

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Stoecklinger A, Eticha TD, Mesdaghi M, Kissenpfennig A, Malissen B, Thalhamer J, Hammerl P

Langerin+ Dermal Dendritic Cells Are Critical for CD8 T Cell Activation and IgH γ-1 Class Switching in Response to Gene Gun Vaccines

J Immunol 186(3), 1377–1383 (2010)

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Weiss R, Scheiblhofer S, Roesler E, Ferreira F, Thalhamer J

Prophylactic mRNA vaccination against allergy

Curr Opin Allergy Clin Immunol 10(6), 567–574 (2010)

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Eckhard U, Schönauer E, Ducka P, Briza P, Nüss D, Brandstetter H

Biochemical characterization of the catalytic domains of three different clostridial collagenases

Biol Chem 390(1), (2009)

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Roesler E, Weiss R, Weinberger EE, Fruehwirth A, Stoecklinger A, Mostböck S, Ferreira F, Thalhamer J, Scheiblhofer S

Immunize and disappear – Safety-optimized mRNA vaccination with a panel of 29 allergens

J Allergy Clin Immunol 124(5), 1070–1077.e11 (2009)

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Schnidar H, Eberl M, Klingler S, Mangelberger D, Kasper M, Hauser-Kronberger C, Regl G, Kroismayr R, Moriggl R, Sibilia M, Aberger F

Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway

Cancer Res 69(4), 1284–1292 (2009)

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Wallner M, Himly M, Neubauer A, Erler A, Hauser M, Asam C, Mutschlechner S, Ebner C, Briza P, Ferreira F

The Influence of Recombinant Production on the Immunologic Behavior of Birch Pollen Isoallergens

PLoS One 4(12), e8457 (2009)

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Eichberger T, Kaser A, Pixner C, Schmid C, Klingler S, Winklmayr M, Hauser-Kronberger C, Aberger F, Frischauf A

GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

J Biol Chem 283(18), 12426–12437 (2008)

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